Solid state stability studies of model dipeptides: aspartame and aspartylphenylalanine
SS Leung, DJW Grant
Index: Leung, Suzanne S.; Grant, David J. W. Journal of Pharmaceutical Sciences, 1997 , vol. 86, # 1 p. 64 - 71
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Citation Number: 54
Abstract
Abstract Some solid-state pharmaceutical properties and the solid-state thermal stability of the model dipeptides aspartame (APM) and aspartylphenylalanine (AP), have been investigated. Studies by differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), high-performance liquid chromatography, powder X-ray diffraction, and optical microscopy have shown that the dipeptides undergo solid state intramo-lecular aminolysis ...
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