Gold-catalyzed synthesis of 2-substituted, 2, 3-disubstituted and 1, 2, 3-trisubstituted indoles in [bmim] BF4
I Ambrogio, A Arcadi, S Cacchi, G Fabrizi, F Marinelli
Index: Ambrogio, Ilaria; Arcadi, Antonio; Cacchi, Sandro; Fabrizi, Giancarlo; Marinelli, Fabio Synlett, 2007 , # 11 p. 1775 - 1779
Full Text: HTML
Citation Number: 18
Abstract
Abstract Cyclization of 2-alkynylanilines in the presence of NaAuCl 4· H 2 O using [bmim] BF 4 as the reaction medium afforded 2-substituted indoles in high yields. The catalyst system was best recycled using n-Bu 4 NAuCl 4. 2, 3-Disubstituted indoles could be prepared from 2-alkynylanilines and 3-buten-2-one through a one-flask annulation-alkylation sequence and 1, 2, 3-trisubstituted indoles were obtained from the same starting materials via an ...
Related Articles:
A total synthesis of (±)-α-cyclopiazonic acid using a cationic cascade as a key step
[Griffiths-Jones, Charlotte M.; Knight, David W. Tetrahedron, 2011 , vol. 67, # 44 p. 8515 - 8528]
Efficient indoles and anilines syntheses employing tert-butyl sulfinamide as ammonia surrogate
[Prakash, Anjanappa; Dibakar, Mullick; Selvakumar, Kumaravel; Ruckmani, Kandasamy; Sivakumar, Manickam Tetrahedron Letters, 2011 , vol. 52, # 43 p. 5625 - 5628]
[Jiao, Lei; Bach, Thorsten Journal of the American Chemical Society, 2011 , vol. 133, # 33 p. 12990 - 12993]
[Ruiz, Miriam; Sanchez, J. Domingo; Lopez-Alvarado, Pilar; Menendez, J. Carlos Tetrahedron, 2012 , vol. 68, # 2 p. 705 - 710]
Gold (I) Iodide catalyzed sonogashira reactions
[Li, Pinhua; Wang, Lei; Wang, Min; You, Feng European Journal of Organic Chemistry, 2008 , # 35 p. 5946 - 5951]