Identification of desmethylcyproheptadine??10, 11??epoxide and other cyproheptadine metabolites isolated from rat urine

…, G Belvedere, C Pantarotto, S Garattini

Index: Frigerio; Sossi; Belvedere; Pantarotto; Garattini Journal of Pharmaceutical Sciences, 1974 , vol. 63, # 10 p. 1536 - 1540

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Citation Number: 30

Abstract

Abstract Desmethylcyproheptadine-10, 11-epoxide, cyproheptadine-10, 11-epoxide, and desmethylcyproheptadine were identified in rat urine collected after administration of 40 mg/kg ip of cyproheptadine. Mass spectrometric characterization confirmed the structure of these metabolites.