The synthesis, characterization, and structure of a series of 4 H-thieno [3, 4-c] pyrroles and their corresponding pyrrolium cyanoborohydride salts

NC Tice, SM Peak, BT Cannon, ES Laha…

Index: Tice, Nathan C.; Peak, Sarah M.; Parkin, Sean Heterocycles, 2010 , vol. 81, # 7 p. 1631 - 1639

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Abstract

A general, convenient route toward N-substituted 5,6-dihydro-4H-thieno[3,4-c]pyrroles was accomplished by the reductive amination of 2,5-dimethylthiophene-3,4-dicarbaldehyde with various primary amines in a solution of sodium cyanoborohydride and methanol/acetic acid (80–88% yield).