Halogenated indole-3-acetic acids as oxidatively activated prodrugs with potential for targeted cancer therapy

S Rossiter, LK Folkes, P Wardman

Index: Rossiter, Sharon; Folkes, Lisa K.; Wardman, Peter Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2523 - 2526

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Citation Number: 44

Abstract

Substituted indole-3-acetic acid (IAA) derivatives, plant auxins with potential for use as prodrugs in enzyme-prodrug directed cancer therapies, were oxidised with horseradish peroxidase (HRP) and toxicity against V79 Chinese hamster lung fibroblasts was ...