Synthesis and Antimicrobial Activity of Pyridines Bearing Thiazoline and Moieties.

HY Hassan, NA El-Koussi, ZS Farghaly

Index: Hassan, Hoda Y.; El-Koussi, Nawal A.; Farghaly, Zeinab S. Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 5 p. 863 - 866

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Citation Number: 33

Abstract

Two series of new pyridines bearing thiazoline (3a-n) and thiazolidinone (5a-e) moieties were prepared via the cyclization of the corresponding substituted pyridyl thiourea (2a-g) with an appropriately substituted phenacyl bromide or chloroacetic acid, respectively. The antimicrobial activity was determined for representative compounds and most of them showed moderate activity against Gram-positive bactera.