Nuclear Magnetic Resonance Spectroscopy. The Configurational Stability of Primary Grignard Reagents. Structure and Medium Effects1

GM Whitesides, JD Roberts

Index: Whitesides,G.M.; Roberts,J.D. Journal of the American Chemical Society, 1965 , vol. 87, p. 4878 - 4888

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Citation Number: 45

Abstract

Qualitative and semiquantitative examination of the temperature dependence of the RCHz- Mg proton nmr spectra of several Grignard reagents indicates that the rate of inversion at this center is relatively insensitive to the structure of the group R. Secondary Grignard reagents invert much more slowly, ifat all. The dependence of the inversion rate of the primary organometallic compounds on solvent character and on added salts suggests that ...