A dual lanthanide probe suitable for optical (Tb 3+ luminescence) and magnetic resonance imaging (Gd 3+ relaxometry)

…, N Geum, I Nasso, B Mestre, P Tisnès, S Laurent…

Index: Picard, Claude; Geum, Neri; Nasso, Isabelle; Mestre, Beatrice; Tisnes, Pierre; Laurent, Sophie; Muller, Robert N.; Elst, Luce Vander Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 20 p. 5309 - 5312

Full Text: HTML

Citation Number: 49

Abstract

A new polyaminocarboxylate ligand derived from N, C-pyrazolylpyridine was synthesized. The luminescence and relaxometry properties of its Tb3+ and Gd3+ chelates were investigated in aqueous solutions. The Tb3+ chelate is strongly luminescent having remarkable lifetime and quantum yield (τ= 1.82 ms and Φ= 0.42). The 1/T1 proton relaxivity at 20MHz and 25° C (5.3 s− 1mM− 1) of the Gd3+ chelate was found to be comparable to ...