Antimicrobial and antineoplastic activities of new 4-diazopyrazole derivatives

…, B Maggio, S Plescia, D Raffa, C Musiu, C Milia…

Index: Daidone, Giuseppe; Maggio, Benedetta; Plescia, Salvatore; Raffa, Demetrio; Musiu, Chiara; Milia, Carlo; Perra, Graziella; Marongiu, Maria Elena European Journal of Medicinal Chemistry, 1998 , vol. 33, # 5 p. 375 - 382

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Citation Number: 86

Abstract

Several new 4-diazopyrazole derivatives were prepared by the reaction of 3-methyl-5 (substituted-benzamido) pyrazoles with an excess of nitrous acid in acetic acid solution. The compounds were tested for antiretroviral activity in HIV-1 infected MT-4 cells and antiproliferative effects against a panel of human leukemia, lymphoma and solid tumor cell lines. They were also tested for activity against representative gram-negative (Shigella, ...