Synthesis and biological evaluation of naphthyldesferrithiocin iron chelators

…, SE Algee, K Ratliff-Thompson

Index: Bergeron, Raymond J.; Wiegand, Jan; Wollenweber, Markus; McManis, James S.; Algee, Samuel E.; Ratliff-Thompson, Katie Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1575 - 1581

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Citation Number: 63

Abstract

The synthesis and iron-clearing properties of the naphthyldesferrithiocins 2-(2'- hydroxynaphth-1'-yl)-Δ2-thiazoline-(4 R)-carboxylic acid, 2-(2'-hydroxynaphth-1'-yl)-Δ2- thiazoline-(4 S)-carboxylic acid, 2-(3'-hydroxynaphth-2'-yl)-Δ2-thiazoline-(4 R)-carboxylic acid, and 2-(3'-hydroxynaphth-2'-yl)-Δ2-thiazoline-(4 S)-carboxylic acid are described. While the bile duct-cannulated rat model clearly demonstrates that the 3'-hydroxynaphthyl-2'-yl ...