Folding of a linear array of α-amino acids within a helical aromatic oligoamide frame

…, V Maurizot, B Kauffmann, A Tanatani…

Index: Kudo, Mayumi; Maurizot, Victor; Kauffmann, Brice; Tanatani, Aya; Huc, Ivan Journal of the American Chemical Society, 2013 , vol. 135, # 26 p. 9628 - 9631

Full Text: HTML

Citation Number: 31

Abstract

Control of the spatial organization of proteinogenic side chains is critical for the development of protein mimics with selective recognition properties toward target protein surfaces. We present a novel methodology for producing a linear array of proteinogenic residues based on the incorporation of α-amino acids into sequences of rigid, helically folded oligoamides of 8-amino-2-quinolinecarboxylic acid (Q). When l-leucine (L) was alternated with dimer Q 2, ...