A total synthesis of 4-hydroxynimesulide

P Singh, A Singh, GC Sharma

Index: Singh, Parmjeet; Singh, Amarjit; Sharma Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 6 p. 1263 - 1264

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Abstract

Pannjeet Singh, Amatjit Singh & GC Sharma* Chemical Research Division, Panacea Biotec Ltd., Chandigarh road, PO Lalru (14050 I), Punjab, India E-mail : gcs harma @pblintranet. com Received 5 Novembcr 2002; accepled (revised) 10 June 2003 ... 4-Hydroxynimesulide, a unique metabolite of Nimesulide has been synthcsized by the formation of 4-lllethoxynilllcsulidc and its subsequent deillethylation with aq. HBr-AcOH/anhyd. AIClr CH2C12·