Tetrahedron

Studies of isocyanides—III: The addition of n, n-dialkylamide chlorides to isocyanides

Y Ito, M Okano, R Oda

Index: Ito,Y. et al. Tetrahedron, 1966 , vol. 22, p. 447 - 454

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Citation Number: 7

Abstract

The reaction of N, N-dimethyl-or N, N-pentamethylene-formamide chlorides with n-butyl, cyclohexyl, and 2, 4-xylyl isocyanides results in the formation of 1: 2-adducts which are readily converted by water to N, N'-disubstituted α-(dialkylamino) malonamides. In the case of N, N-dimethylamide chlorides of acetic, propionic, and benzoic acids, the products are the corresponding N-substituted α-ketoamides resulting from hydrolysis of 1: 1-adducts and ...