Exploring the relation between amplification and binding in dynamic combinatorial libraries of macrocyclic synthetic receptors in water

PT Corbett, JKM Sanders, S Otto

Index: Corbett, Peter T.; Sanders, Jeremy K.M.; Otto, Sijbren Chemistry - A European Journal, 2008 , vol. 14, # 7 p. 2153 - 2166

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Citation Number: 64

Abstract

Abstract Herein we describe an extensive study of the response of a set of closely related dynamic combinatorial libraries (DCLs) of macrocyclic receptors to the introduction of a focused range of guest molecules. We have determined the amplification of two sets of diastereomeric receptors induced by a series of neutral and cationic guests, including biologically relevant compounds such as acetylcholine and morphine. The host–guest ...