Organic letters

First direct reductive amination of mucochloric acid: a simple and efficient method for preparing highly functionalized α, β-unsaturated γ-butyrolactams

J Zhang, PG Blazecka, JG Davidson

Index: Zhang; Blazecka, Peter G; Davidson, James G Organic letters, 2003 , vol. 5, # 4 p. 553 - 556

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Citation Number: 50

Abstract

The first direct reductive amination of mucochloric acid (1) has been accomplished. Reaction of 1 with various alkyl, aryl, and benzylamines, followed by reduction in the same pot, provides an efficient method of obtaining N-benzyl-3, 4-dichloro-1, 5-dihydro-pyrrol-2-one and N-aryl (or alkyl)-3, 4-dichloro-1, 5-dihydro-pyrrol-2-ones.