Journal of heterocyclic chemistry

Synthesis of racemic and enantiomerically pure 2′??thia??2′, 3′??dideoxycytidine as potential anti??hepatitis B virus agents

BC Pan, YC Cheng, SH Chu

Index: Pan, Bai-Chuan; Cheng, Yung-Chi; Chu, Shih-Hsi Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 909 - 915

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Citation Number: 2

Abstract

Abstract A novel class of nucleosides with the C 1, atom bonded to three hetero atoms was synthesized. 2′-Thia-2′, 3′-dideoxycytidine was the pilot compound of this series.(±)-β- 2′-Thia-1′, 3′-dideoxycytidine (6) and (±)-α-2′-thia-2′, 3′-dideoxycytidine (7) were synthesized from (±)-3-mercapto-1, 2-propanediol. The synthesis of the enantiomerically pure 2′-thia-2′, 3′-dideoxycytidines (α-D-form, β-D-form, α-1-form and β-L-form) from ...