Side chain and backbone structure-dependent subcellular localization and toxicity of conjugated polymer nanoparticles

E Mendez, JH Moon

Index: Mendez, Eladio; Moon, Joong Ho Chemical Communications, 2013 , vol. 49, # 54 p. 6048 - 6050

Full Text: HTML

Citation Number: 6

Abstract

The subcellular localization and toxicity of conjugated polymer nanoparticles (CPNs) are dependent on the chemical structure of the side chains and backbone. Primary amine- containing CPNs exhibit high Golgi localization with no toxicity. Incorporation of short ethylene oxide and tertiary amine side chains contributes to decreased Golgi localization and increased toxicity, respectively.