Synthesis of perimidine and 1, 5-benzodiazepine derivatives using tamed Brønsted acid, BF 3–H 2 O

GKS Prakash, F Paknia, A Narayan, T Mathew…

Index: Prakash, G. K. Surya; Paknia, Farzaneh; Narayan, Arjun; Mathew, Thomas; Olah, George A. Journal of Fluorine Chemistry, 2013 , vol. 152, p. 99 - 105

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Citation Number: 10

Abstract

The one pot synthesis of perimidine and 1, 5-benzodiazepine derivatives via condensation of aryldiamines with ketones in the presence of BF3–H2O is described. BF3–H2O plays a dual role, as an efficient non-oxidizing Brønsted acid catalyst as well as an effective solvent making the reaction more economic and environmentally safer. The reaction is simple, fast and convenient.