3??Aryl??4??methyl??2??quinolones Targeting Multiresistant Staphylococcus aureus Bacteria

…, O Fendrich, E Bergeron, A Montagut??Romans…

Index: Doleans-Jordheim, Anne; Veron, Jean-Baptiste; Fendrich, Olivier; Bergeron, Emmanuelle; Montagut-Romans, Adrien; Wong, Yung-Sing; Furdui, Bianca; Freney, Jean; Dumontet, Charles; Boumendjel, Ahcene ChemMedChem, 2013 , vol. 8, # 4 p. 652 - 657

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Citation Number: 15

Abstract

Abstract The NorA efflux pump lowers intracellular fluoroquinolone concentrations by expelling antibiotics through the membrane of Staphylococcus aureus. We identified 3-aryl-4- methyl-2-quinolin-2-ones as compounds able to restore the activity of the NorA substrate, ciprofloxacin, against resistant S. aureus strains, and acting as efflux pump inhibitors (EPI). In particular, 5-hydroxy-7-methoxy-4-methyl-3-phenylquinolin-2-one (6 c) presents both ...