Design and development of 2, 3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists
R Gitto, M Zappalà, G De Sarro, A Chimirri
Index: Gitto, Rosaria; Zappala, Maria; De Sarro, Giovambattista; Chimirri, Alba Farmaco, 2002 , vol. 57, # 2 p. 129 - 134
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Citation Number: 27
Abstract
2, 3-Benzodiazepines represent a class of heterocyclic compounds that interact with AMPA- type glutamate receptors in a noncompetitive manner. These compounds have attracted great interest for their pharmacological effects against acute and chronic neurodegenerative diseases, such as ischemia and epilepsy. We synthesized a large number of 2, 3- benzodiazepine derivatives, which showed anticonvulsant properties in different seizure ...
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