The Journal of organic chemistry

Total synthesis of (±)-rhazinal using novel palladium-catalyzed cyclizations

AL Bowie Jr, D Trauner

Index: Bowie, Alfred L.; Trauner, Dirk Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1581 - 1586

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Citation Number: 75

Abstract

A concise synthesis of (±)-rhazinal that hinges on novel oxidative Heck cyclizations and palladium-catalyzed direct couplings is described. An X-ray structure of N-MOM-rhazinal, which provides insight into the conformation of the strained 9-membered lactam ring, is described.