Synthesis and biological evaluation of new [Tc (N)(PS)]-based mixed-ligand compounds useful in the design of target-specific radiopharmaceuticals: the 2- …

…, N Salvarese, D Carta, F Refosco, A Dolmella…

Index: Bolzati, Cristina; Salvarese, Nicola; Carta, Davide; Refosco, Fiorenzo; Dolmella, Alessandro; Pietzsch, Hans Juergen; Bergmann, Ralf; Bandoli, Giuliano Journal of Biological Inorganic Chemistry, 2011 , vol. 16, # 1 p. 137 - 155

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Citation Number: 8

Abstract

Abstract This study presents the first application of a general procedure based on the use of the [Tc (N) Cl (PS)(PPh 3)] species (PS is an alkyl phosphinothiolate ligand) for the preparation of Tc (N) target-specific compounds.[Tc (N) Cl (PS)(PPh 3)] selectively reacts with an appropriate dithiocarbamate ligand (S∧ Y) to give [Tc (N)(PS)(S∧ Y)] compounds. 1- (2-Methoxyphenyl) piperazine, which displays a potent and specific affinity for 5HT 1A ...

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