Synthesis of novel cationic lipids: effect of structural modification on the efficiency of gene transfer

JA Heyes, D Niculescu-Duvaz, RG Cooper…

Index: Heyes; Niculescu-Duvaz; Cooper; Springer Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 99 - 114

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Citation Number: 166

Abstract

A series of novel cationic lipids was designed and synthesized in an effort to understand the importance of the various structural features with respect to transfection efficiency. Particular attention has been paid to the hydrophobic domain and the cationic headgroup. An efficient method of synthesizing asymmetric diether lipids is described, using alkyl chains ranging from C12 to C18 and the unsaturated oleyl group. The ternary formulations including the ...