A new class of phosphanucleosides containing a 3-hydroxy-1-hydroxymethylphospholane 1-oxide ring
O Páv, E Zbornikova, M Buděšínský, I Rosenberg
Index: Pav, Ondrej; Zbornikova, Eva; Budesinsky, Milos; Rosenberg, Ivan Tetrahedron, 2013 , vol. 69, # 43 p. 9120 - 9129
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Abstract
Abstract Novel phosphanucleosides containing a 3-hydroxy-1-hydroxymethylphospholane 1- oxide ring were synthesized as compounds with potential biological activity. A double Arbuzov reaction was employed to prepare a phospholene precursor, which was then converted into an epoxide and subsequently into racemic phosphanucleoside via nucleobase construction.
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