Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity
C Changtam, P Hongmanee, A Suksamrarn
Index: Changtam, Chatchawan; Hongmanee, Poonpilas; Suksamrarn, Apichart European Journal of Medicinal Chemistry, 2010 , vol. 45, # 10 p. 4446 - 4457
Full Text: HTML
Citation Number: 71
Abstract
Curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3), the curcuminoid constituents of the medicinal plant Curcuma longa L., have been structurally modified to 55 analogs and antimycobacterial activity against Mycobacterium tuberculosis has been evaluated. Among the highly active curcuminoids, the isoxazole analogs are the most active group, with mono-O-methylcurcumin isoxazole (53) being the most active compound (MIC ...
Related Articles:
[Endo, Katsuya; Kanno, Emi; Oshima, Yoshiteru Phytochemistry (Elsevier), 1990 , vol. 29, # 3 p. 797 - 799]
Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs
[Lee, Su-Lin; Huang, Wei-Jan; Lin, Wan Wan; Lee, Shoei-Sheng; Chen, Chung-Hsiung Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 22 p. 6175 - 6181]
Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs
[Lee, Su-Lin; Huang, Wei-Jan; Lin, Wan Wan; Lee, Shoei-Sheng; Chen, Chung-Hsiung Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 22 p. 6175 - 6181]
[Matsuda, Hisashi; Tewtrakul, Supinya; Morikawa, Toshio; Nakamura, Akihiko; Yoshikawa, Masayuki Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 22 p. 5891 - 5898]
Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver
[Hoehle, Simone I.; Pfeiffer, Erika; Solyom, Aniko M.; Metzler, Manfred Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 3 p. 756 - 764]