A new approach to the synthesis of lamotrigine and other 3, 5-diamino-1, 2, 4-triazine derivatives

EN Ulomskii, TS Shestakova, SL Deev…

Index: Ulomskii; Shestakova; Deev; Rusinov; Chupakhin Russian Chemical Bulletin, 2005 , vol. 54, # 3 p. 726 - 732

Full Text: HTML

Citation Number: 8

Abstract

Abstract A new in principle method for the synthesis of 6-aryl (hetaryl)-3, 5-diamino-1, 2, 4- triazines by decomposition of pre-synthesized tetrazolo [1, 5-b][1, 2, 4] triazines was developed. The advantages of this method over traditional methods were demonstrated using the synthesis of a modern antiepileptic preparation lamotrigine, as an example.