Wittig gem-difluoroolefination of aldehydes with difluoromethyltriphenylphosphonium bromide

…, JH Lin, ZY Deng, J Zheng, J Cai, JC Xiao

Index: Li, Qiang; Lin, Jin-Hong; Deng, Zu-Yong; Zheng, Jian; Cai, Ji; Xiao, Ji-Chang Journal of Fluorine Chemistry, 2014 , vol. 163, p. 38 - 41

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Citation Number: 16

Abstract

Abstract Wittig reaction of aldehydes with difluoromethyltriphenylphosphonium bromide leading to gem-difluoroolefins in moderate yields is described. The reaction displays a good substrate scope including aryl, heteroaryl and α, β-unsaturated aldehydes. Difluoromethyltriphenylphosphonium bromide could be easily prepared and stored for a long time under air atmosphere. The salt exhibits high thermal stability demonstrated by ...

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