Carbonic anhydrase inhibitors—Part 29 1: Interaction of isozymes I, II and IV with benzolamide-like derivatives

CT Supuran, MA Ilies, A Scozzafava

Index: Supuran, Claudiu T.; Ilies, Marc A.; Scozzafava, Andrea European Journal of Medicinal Chemistry, 1998 , vol. 33, # 9 p. 739 - 751

Full Text: HTML

Citation Number: 112

Abstract

Reaction of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-imino-4-tnethyl-2-sulfonamido- δ2-1, 3, 4-thiadiazoline with sulfonyl halides/sulfonic acid anhydrides afforded benzolamide- like derivatives possessing very strong inhibitory effects towards three isozymes of carbonic anhydrase (CA), CA I, II and IV. Some of the compounds were designed in such a way to possess good leaving groups (such as nitro-; 2, 4, 6-triphenyl-pyridinium, etc.) for aromatic ...