Laboratory scale preparation of 4, 4, 5, 5, 5-pentafluoropentan-1-thiol: an important chain of anti-breast cancer agents
X Li, L Provencher, SM Singh
Index: Li, Xun; Provencher, Louis; Singh, Shankar M. Tetrahedron Letters, 1994 , vol. 35, # 49 p. 9141 - 9144
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Citation Number: 8
Abstract
Abstract Quantitative free radical addition of perfluoroethyl iodide to propargyl alcohol in the presence of sodium hydrosulfite gave E/Z-2-iodo-4, 4, 5, 5, 5-pentafluoro-2-penten-1-ols, which were converted to 4, 4, 5, 5, 5-pentafluoropentan-1-ol in one step in excellent yield by catalytic hydrogenation over platinum oxide in the presence of triethylamine. 4, 4, 5, 5, 5- Pentafluoropentan-1-thiol was obtained in good yield via modified Mitsunobu reaction of ...
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