Tetrahedron

First total synthesis of the mastigophorenes C and D and of simplified unnatural analogs

G Bringmann, T Pabst, P Henschel, M Michel

Index: Bringmann, Gerhard; Pabst, Thomas; Henschel, Petra; Michel, Manuela Tetrahedron, 2001 , vol. 57, # 7 p. 1269 - 1275

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Citation Number: 22

Abstract

The first total synthesis of the mastigophorenes C (2) and D (3), natural 'dimeric' sesquiterpenes isolated from the liverwort Mastigophora diclados with interesting biological activities, is described. As previously for mastigophorenes A (1) and B, the divergent synthetic approach was first optimized on a simplified model system with a tert-butyl group instead of the chiral cyclopentyl residue, also in order to find more easily available ...