Tetrahedron letters

A practical synthetic method for vinyl chlorides and vinyl bromides from ketones via the corresponding vinyl phosphate intermediates

K Kamei, N Maeda, T Tatsuoka

Index: Kamei, Katsuhide; Maeda, Noriko; Tatsuoka, Toshio Tetrahedron Letters, 2005 , vol. 46, # 2 p. 229 - 232

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Citation Number: 18

Abstract

Vinyl halides have become important intermediates in organic synthesis for C–C and C–N bond formation such as Pd-catalyzed coupling reaction 1 and vinyl radical cyclization. 2 Recently, we have reported SUN N4057, which has a vinyl chloride moiety, as a pharmaceutical candidate for the treatment of acute phase of cerebral infarction (Figure 1). 3 In this research project, we need to develop a practical synthetic method for vinyl halides. Although vinyl halides in ...