A novel class of potential central nervous system agents. 3-phenyl-2-(1-piperazinyl)-5H-1-benzazepines

K Hino, Y Nagai, H Uno, Y Masuda, M Oka…

Index: Hino; Nagai; Uno; Masuda; Oka; Karasawa Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 107 - 117

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Citation Number: 21

Abstract

A series of 3-phenyl-2-piperazinyl-5H-l-benzazepines and related compounds were synthesized and evaluated for potential neuroleptic activity. The preparation of these compounds was carried out by 2, 3-dichlorination of 3-phenyl-2, 3, 4, 5-tetrahydro-lH-l- benzazepin-2-ones with phosphorus pentachloride followed by amination and concurrent dehydrochlorination. Compounds having the 4-chloro or 4-fluor0 substituent in the 3- ...