Synthesis and acylation of 2??nitro??11H??dibenzo [b, e][1, 4] dioxepin

WK Hagmann, LA O'Grady, CP Dorn…

Index: Hagmann; O'Grady; Dorn; Springer Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 673 - 677

Full Text: HTML

Citation Number: 2

Abstract

The synthesis of aryl tricyclic compounds having two benzo groups fused around a central seven-membered ring has been important to the development of two classes of drugs, the antidepressants [ 11 and the non-steroidal antiin- flammatory drugs (NSAIDS) 121. Many heterocycles have appeared in the central ring. Substituted 1 1H-dibenzo- [b,e][l,4]dioxepins (1 IH-DBDO) were synthesized for use as antidepressants [3]. More recently, the IlH-DBDO ring system has appeared as ...