Journal of pharmaceutical sciences

Synthesis and pharmacology of some basic esters of 3, 4, 5??trimethoxybenzoic acid

AJ Vazakas, JT Doluisio

Index: Vazakas,A.J.; Doluisio,J.T. Journal of Pharmaceutical Sciences, 1964 , vol. 53, # 2 p. 165 - 169

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Citation Number: 3

Abstract

Abstract A series of basic esters of 3, 4, 5-trimethoxybenzoic acid has been synthesized and the compounds evaluated for antihypertensive and local anesthetic activity. One of the compounds, a diamine ester prepared from N-methyl-N-phenyl-N′-propyl-ethylenediamine via a three-step synthesis, exhibited hypotensive activity following intravenous administration to normotensive dogs. No hypotensive activity was demonstrated following ...