Iridium (I)??Catalyzed Direct C H Bond Alkylation of the C??7 Position of Indolines with Alkenes
S Pan, N Ryu, T Shibata
Index: Pan, Shiguang; Ryu, Naoto; Shibata, Takanori Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 929 - 933
Full Text: HTML
Citation Number: 37
Abstract
Abstract: A cationic iridium-catalyzed C-7 alkylation of N-substituted indoline derivatives with various alkenes has been developed. A variety of 7-alkylACHTUNGTRENNUNGindolines were obtained in moderate to high yields. This protocol relies on the use of the carbonyl group on the nitrogen atom of indoline as a directing group and it is potentially applicable to the large-scale synthesis of 7-alkylindoles. Keywords: alkenes; alkylation; CÀH ...
Related Articles:
Preparation of differentially 1, 3-disubstituted indolines by intramolecular carbolithiation
[Bailey, William F.; Luderer, Matthew R.; Mealy, Michael J. Tetrahedron Letters, 2003 , vol. 44, # 28 p. 5303 - 5305]
Iridium??Catalyzed Asymmetric Hydrogenation of N??Protected Indoles
[Baeza, Alejandro; Pfaltz, Andreas Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2036 - 2039]
[Togo, Hideo; Kikuchi, Osamu Heterocycles, 1989 , vol. 28, # 1 p. 373 - 381]
[Togo, Hideo; Kikuchi, Osamu Heterocycles, 1989 , vol. 28, # 1 p. 373 - 381]
[Togo, Hideo; Kikuchi, Osamu Heterocycles, 1989 , vol. 28, # 1 p. 373 - 381]