Tetrahedron letters

Studies on trifluoromethylphosphonamidite analogues as building blocks in oligonucleotide synthesis

M Mayer, I Ugi, W Richter

Index: Mayer, Michael; Ugi, Ivar; Richter, Wolfgang Tetrahedron Letters, 1995 , vol. 36, # 12 p. 2047 - 2050

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Citation Number: 5

Abstract

The phosphorylating reagents CF3P (NMe2) Cl and CF3P (NEt2) Cl are used to phosphorylate the 3′-hydroxyl moiety of several protected 2′-deoxynucleosides yielding the corresponding nucleoside trifluoromethyl phosphonamidites. Their scope and limitations towards amidite activation are investigated but, however, their behavior is completely different to commonly used nucleoside phosphorus amidites.