Tetrahedron Letters

Sodium carbonate mediated regioselective synthesis of novel N-(hydroxyalkyl) cinnamamides

P Garg, MD Milton

Index: Garg, Parul; Milton, Marilyn Daisy Tetrahedron Letters, 2013 , vol. 54, # 51 p. 7074 - 7077

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Citation Number: 2

Abstract

Abstract A synthetic protocol for the direct synthesis of N-(hydroxyalkyl) cinnamamides from cinnamates and aminoalcohols in the presence of sodium carbonate as the base is presented. A wide variety of N-(hydroxyalkyl) cinnamamides were isolated in up to 99% yields. The reaction is highly regioselective and yields only N-acylated products by 1, 2- addition of aminoalcohols to cinnamates.