One-Pot Synthesis of Cefpirome Sulfate from GCLE

…, Y Lu, J Han, L Chen, P Zheng

Index: Duan, Xuemin; Lu, Yao; Han, Juan; Chen, Ligong; Zheng, Pengwu Synthetic Communications, 2011 , vol. 41, # 5 p. 629 - 636

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Abstract

Cefpirome was synthesized in 37.7% overall yield from 3-chloromethyl-7-phenylacetylamino cephalosporanic acid p-methoxybenzyl ester (GCLE) by sequential substitution of C-3 chloride with iodide and 2, 3-cyclopentenopyridine, followed by a one-pot procedure including deprotection of carboxyl group, hydrolysis of 7-phenylacetamido, and reaction with 2-mercaptobenzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate (MAEM). ...