Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B

…, G Terre'Blanche, ACU Lourens, A Petzer…

Index: Van Der Walt, Mietha M.; Terre'Blanche, Gisella; Lourens, Anna C.U.; Petzer, Anel; Petzer, Jacobus P. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7367 - 7370

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Citation Number: 3

Abstract

It has recently been reported that nitrile containing compounds frequently act as potent monoamine oxidase B (MAO-B) inhibitors. Modelling studies suggest that this high potency inhibition may rely, at least in part, on polar interactions between nitrile functional groups and polar moieties within the MAO-B substrate cavity. In an attempt to identify potent and selective inhibitors of MAO-B and to contribute to the known structure–activity ...