An Efficient Copper??Catalyzed Cross??Coupling Reaction of Thiols with Aryl Iodides

HL Kao, CK Chen, YJ Wang…

Index: Kao, Hsin-Lun; Chen, Chin-Keng; Wang, Yu-Jen; Lee, Chin-Fa European Journal of Organic Chemistry, 2011 , # 9 p. 1776 - 1781

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Citation Number: 10

Abstract

Abstract Commercially available Cu 2 O powder is a very reactive catalyst for the coupling of thiols to aryl iodides. A variety of functional groups including esters, unprotected amines, alcohols, and heterocycles tolerate the reaction conditions. Moreover, di-ortho-substituted aryl iodides with sterically demanding substrates were also coupled to give the desired aryl thioethers in good to excellent yields.