Synthesis and antifungal activity of 6-hydroxycinnolines
CK Ryu, JY Lee
Index: Ryu, Chung-Kyu; Lee, Jung Yoon Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1850 - 1853
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Citation Number: 11
Abstract
6-Hydroxycinnolines 2 and cyclohexa-2, 5-diene-1, 4-dione derivatives 6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 6- Hydroxycinnolines 2 showed, in general, more potent antifungal activity against Candida species than the other cyclohexa-2, 5-diene-1, 4-diones. The results suggest that 6- hydroxycinnolines would be potent antifungal agents.
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