Tetrahedron: Asymmetry

'Green'synthesis of important pharmaceutical building blocks: enzymatic access to enantiomerically pure α-chloroalcohols

D Zhu, C Mukherjee, L Hua

Index: Zhu, Dunming; Mukherjee, Chandrani; Hua, Ling Tetrahedron Asymmetry, 2005 , vol. 16, # 19 p. 3275 - 3278

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Citation Number: 68

Abstract

Thirty one recombinant ketoreductase enzymes were screened for the reduction of six α- chloroketones, the precursors of pharmaceutically valuable α-chloroalcohols. Several highly active and enantioselective ketoreductases were found and their applications to the synthesis of both enantiomers of these α-chloroalcohols were demonstrated on a preparative scale. This offers a convenient,'green'access to this type of important ...