Tetrahedron: Asymmetry

A general asymmetric synthesis of phenylglycinols

X Pan, L Jia, X Liu, H Ma, W Yang, JB Schwarz

Index: Pan, Xingang; Jia, Liangbin; Liu, Xuejian; Ma, Haikuo; Yang, Wenqian; Schwarz, Jacob B. Tetrahedron Asymmetry, 2011 , vol. 22, # 3 p. 329 - 337

Full Text: HTML

Citation Number: 2

Abstract

For decades, enantiomerically pure phenylglycinol has been exploited as a key building block for asymmetric reaction methodology. 1 Of the general asymmetric approaches to phenylglycinols reported to date, only moderate efficiencies have been obtained. Hence, the ability to electronically or sterically tune such motifs in a systematic manner, for instance in the design of novel catalysts, has been somewhat limited. One innovative approach toward solving this ...