Synthesis of [1] benzopyrano [4, 3-b] pyrrol-4 (1H)-ones from 4-chloro-3-formylcoumarin

A Alberola, L Calvo, A González-Ortega, AP Encabo…

Index: Alberola; Calvo; Gonzalez-Ortega; Encabo; Sanudo Synthesis, 2001 , # 13 p. 1941 - 1948

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Citation Number: 11

Abstract

Abstract 2-Functionalized [1] benzopyrano [4, 3-b] pyrrol-4 (1H)-ones were obtained by the Fischer-Fink reaction starting from 4-chloro-3-formylcoumarin and different α-amino derivatives (eg glycinonitriles, ethyl glycinates and α-amino ketones). In general limitations to the synthetic method arise when α-amino derivatives with very reactive functions were used (eg carboxaldehyde groups or their acetal derivatives) leading to Knorr type ...