α-Benzyldopamine and some related compounds: Synthesis and pharmacological screening

V Valenta, A Dlabač, M Valchář…

Index: Valenta; Dlabac; Valchar; Protiva Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 4 p. 1002 - 1008

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Abstract

Abstract Claisen reaction of 3, 4-dimethoxyphenylacetonitrile with ethyl phenylacetate, the following stepwise hydrolysis and decarboxylation afforded the amide V 1-(3, 4- dimethoxyphenyl)-3-phenylpropan-2-one (VI). Leuckart reaction resulted in the crude formamide derivative IIIb which was subjected to alkaline hydrolysis to the primary amine Ib on the one hand, and to reduction to the secondary amine IIb on the other. Demethylation ...