Synlett

Scandium (III) Fluoride as a Novel Catalyst for Hydroxymethylation of Dimethylsilyl Enolates in Aqueous Media

M Kokubo, S Kobayashi

Index: Kokubo, Masaya; Kobayashi, Shu Synlett, 2008 , # 10 p. 1562 - 1564

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Citation Number: 2

Abstract

Abstract Hydroxymethylation of dimethylsilyl (DMS) enolates using aqueous formaldehyde solution is catalyzed by scandium (III) fluoride (ScF 3) in aqueous media to give the corresponding β-hydroxy ketones in good to excellent yields. Whilst the DMS enolate