Synthesis of multivalent β-lactosyl clusters as potential tumor metastasis inhibitors

B Dean, H Oguchi, S Cai, E Otsuji, K Tashiro…

Index: Dean, Barbara; Oguchi, Hisao; Cai, Shaopei; Otsuji, Eigo; Tashiro, Kazuhiro; et al. Carbohydrate Research, 1993 , vol. 245, # 2 p. 175 - 192

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Citation Number: 37

Abstract

Abstract A β-lactosyl residue was linked to the amino groups of l-lysyl-l-lysine through spacer arms of three different lengths (C 2, C 4, and C 9) to give trivalent β-lactosyl clusters in order to increase the inhibitory activity of the β-lactosyl group against tumor cell colonization. Thus, O-(2, 3, 4, 6-tetra-O-acetyl-β-d-galactopyranosyl)-(1→-4)-2, 3, 6,-tri-O- acetyl-glucopyranosyl trichloroacetimidate was treated with methyl or benzyl ...

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