Synthesis and utility of the 3, 3-dimethyl-5-substituted-2-pyrrolidinone 'Quat'chiral auxiliary

SG Davies, DJ Dixon, GJM Doisneau, JC Prodger…

Index: Davies, Stephen G.; Dixon, Darren J.; Doisneau, Gilles J.-M.; Prodger, Jeremy C.; Sanganee, Hitesh J. Tetrahedron Asymmetry, 2002 , vol. 13, # 6 p. 647 - 658

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Citation Number: 26

Abstract

The synthesis and utility of the 3, 3-dimethyl-5-substituted-2-pyrrolidinone 'Quat'chiral auxiliary in stereoselective enolate reactions of attached N-acyl side chains combined with the mild and non-racemising conditions required for the ultimate removal of the chiral side chain is described.

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