Synthesis and anticancer evaluation of bis (benzimidazoles), bis (benzoxazoles), and benzothiazoles
ST Huang, IJ Hsei, C Chen
Index: Huang, Shu-Ting; Hsei, I-Jen; Chen, Chinpiao Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 17 p. 6106 - 6119
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Citation Number: 230
Abstract
Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15–18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity ...
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