Demethylation studies. IV. The in vitro and in vivo cleavage of alkyl-and arylalkyl-p-nitrophenyl ethers

RE McMahon, HW Culp, J Mills…

Index: McMahon,R.E. et al. J. Med. Chem., 1963 , vol. 6, p. 343 - 346

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Citation Number: 50

Abstract

Methods. Microsomee.-The livers of iiornwl m: de rats were quii~ kl~~ removed. folio.[-in T de,:. p: taL'cin. nnd p': t (. ed in ice ro! d 0.1. Ii phoq) hnte bu" er. pH 7.4.? he livers were weighed, minced, and put into a (* old Potter-E1veh: eni homogenizer. Phosphate buffer ivas added in the rat, io of 1: I and the livers were homogenized with: I Teflon pestle for 1-1.5 min. The pooled honiogenates', rere caentrifuged at 20,000/for 30 niin. in: t Spinco LIiidel I ...